BIOPRECURSOR PRODRUGS PDF

THE DIFFERENT KINDS OF PRODRUGS A. Defi nitions and classifi cations B. The carrier prodrug principle C. The bioprecursor-prodrug principle D. Other. Bioprecursor Prodrugs. Phosphorylation example –. Bioprecursor Prodrugs. We have already seen 2 examples of this: Sulfasalazine – an azo compound. Bioprecursor Prodrugs: Molecular Modification of the Active Principle Keywords: Bioprecursor prodrugs, active metabolites, oxidative activation, glucuronic.

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Bioprecursor prodrugs: molecular modification of the active principle.

Powered by SMF 2. About project SlidePlayer Terms of Service. We think you have liked this presentation. We think you have liked this presentation. Examples of Carrier-linked Bipartate Prodrugs 3. Prodrugs for Site Specificity a. About project SlidePlayer Terms of Service. If you wish to download it, please recommend it to your friends in any biopredursor system.

Registration Forgot your password? Know some examples of currently used prodrugs. Enzymes — not just your run of the mill protein! Registration Forgot your password?

Why have prodruhs prodrugs if they are not utilised for the purpose of increasing the rate of transportation across the cell membrane? Awesome, that makes a lot of sense. Cookies help prodruhs provide you a better browsing experience. Prodrugs to encourage patient acceptance clindamycin antibacterial. Enter the body by crossing barriers Distributed by the blood to the site of action Biotransform.

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This may be helpful for increasing bioavailability, or also bioprwcursor the drug itself is nonspecific in its action. Methenamine the lower the pH, the faster the rate of formaldehyde formed blood pH 7.

Bioprecursor Prodrugs

Published by Aubrey Johnston Modified over 3 years ago. Understand how a drug candidate can be modified to generate a prodrug 3.

OK Is the passage of drug from its site of administration to its site of action through cell membranes. Published by Aubrey Johnston Modified over 3 years ago. Prodrug readily transported to the site of action Prodrug is rapidly absorbed at the site Selective and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: If you wish to download it, please recommend it to your friends in any social system.

Presentation Description Prodrugs, medicinal chemistry. Epinephrine anti-glaucoma dipivefrin esterase PowerPoint Presentation: Prodrugs to minimize toxicity aspirin anti-inflammatory ester derivative of aspirin a.

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Definition of bioprecursor_prodrug – Chemistry Dictionary

To make this website work, we log user data and share it with processors. To use this website, you must agree to our Privacy Policyincluding cookie policy. Prodrug readily transported to the site of action Prodrug is rapidly absorbed at the site Selective and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: Download ppt bilprecursor Prodrugs”.

Oxidative Activation 5, 6 dihydropyridine bioprecursor d. If it were nonspecific, then having the drug administered could cause unwanted side effects or toxicity before even reaching its target. Examples of Carrier-linked Bipartate Prodrugs 5.