Original Article from The New England Journal of Medicine — Oral Apixaban for the Treatment of Acute Venous Thromboembolism. Apixaban, an oral, direct factor Xa inhibitor, may reduce the risk of recurrent ischemic events when added to antiplatelet therapy after an acute coronary. Original Article from The New England Journal of Medicine — Apixaban in Patients with Atrial Fibrillation.
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Patients with active malignancies are at risk for VTE but do not always receive prophylactic anticoagulants because of concerns about bleeding, need for injections, and cost.
FDA approves antidote for factor Xa inhibitors
In patients with atrial fibrillation, apixaban was superior to warfarin in preventing stroke or systemic embolism, caused less bleeding, and resulted in lower mortality. The rate of major bleeding was 2. N Engl J Med Dec 4. About andexanet alfa Andexanet alfa is a modified human factor Xa molecule that acts as a decoy to target and sequester both oral and injectable factor Xa inhibitors in the blood. N Engl J Med Dec 1. Portola Pharmaceuticals first submitted the biologics license application BLA for andexanet alfa in December In this randomized, double-blind trial, we compared apixaban at a dose of 5 mg twice daily with warfarin target aplxaban normalized ratio, 2.
Thromboprophylaxis with Apixaban for Cancer Patients
The FDA had already granted andexanet alfa orphan drug designation earlier in and breakthrough therapy designation in DOACs appear to be as effective as LMWH and are more acceptable to patients, but they pose similar risks for bleeding and should be used cautiously in those with gastrointestinal malignancies, renal impairment, or thrombocytopenia. This study is scheduled to start inwith results expected to be available in Gradishar, MD Highlights of the latest research.
Wenn Sie fortfahren, nehmen wir an, dass Sie mit der Verwendung von Cookies auf dieser Webseite einverstanden sind. The trial was designed to test for noninferiority, with key secondary objectives of testing for superiority with respect to the primary outcome and to the rates of major bleeding and death from any cause. J Clin Oncol Dec 7 National Comprehensive Cancer Network guidelines for multigene panel testing miss nearly half of patients with actionable variants.
Comment Patients with active malignancies are at risk for VTE but do not always receive prophylactic anticoagulants because of concerns about bleeding, need for injections, and cost. The rate of the primary outcome was 1.
No between-group differences were seen in the rates of adverse events and deaths.
Expert Opin Investig Drugs. Lancet Oncol Nov 1. Vitamin K antagonists are highly effective in preventing stroke in patients with atrial fibrillation but have several limitations.
FDA approves antidote for factor Xa inhibitors |
N Engl J Med Dec 1 Older patients with previously untreated disease had better outcomes with ibrutinib than with chemo-immunotherapy.
Carrier M et al. Blood Dec 3.
A broader commercial launch of andexanet alfa is anticipated in earlydependent upon FDA approval of the generation 2 manufacturing process. Comment in N Engl J Med. Apixaban or placebo was given within 24 hours of starting chemotherapy and continued for 6 months.
Venous thromboembolism occurred less frequently with the direct oral anticoagulant apixaban than with placebo. The primary outcome was ischemic or apixabab stroke or systemic embolism. Ravulizumab was noninferior to eculizumab in both previously treated and treatment-naive patients.
In Augustthe FDA issued a complete response letter explaining why the agency could not approve andexanet alfa for this indication. Whether direct oral anticoagulants DOACs would be safe and effective for this indication xpixaban unclear. N Engl J Med Dec 4 Venous thromboembolism occurred less frequently with the direct oral anticoagulant apixaban than with placebo. The median duration of follow-up was 1. N Engl J Med Dec 13 At 23 years of follow-up, life expectancy was nearly 3 years longer with prostatectomy than with watchful waiting.
VTE was less frequent in patients assigned to apixaban versus placebo 4. Genetic Testing for Breast Cancer: N Engl J Med Dec 4; [e-pub].
Andexanet alfa is approved for use in patients treated with rivaroxaban or apixaban when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding. Forty percent of patients with relapsed or refractory disease achieved complete remission. Once bound, the factor Xa inhibitors are unable to bind to and inhibit native factor Xa, thus potentially allowing for the restoration of normal hemostatic processes.
Blood Dec 3 Ravulizumab was noninferior to eculizumab in both previously treated and treatment-naive patients.